Filip Klimeš, former PhD candidate of Vogel-Claussen Imaging Lab, has successfully defended his PhD thesis entitled "3D Dynamic functional lung ventilation magnetic resonance imaging". Focus of his work was on 3D Phase resolved functional lung (PREFUL) MRI to quantify ventilation during free breathing in healthy volunteers and patients with obstructive lung disease.

Two abstracts from members of Vogel-Claussen Imaging lab at this year's ISMRM annual meeting were among the highest rated 15% as judged by abstract reviewers.  The first Magna Cum Laude Merit Award is bestowed upon the abstract "Registration on different lung volumes and its influence on venlation and perfusion parameters derived by phase-resolved funconal lung MRI" by Klimes et al, the second award for "Pulmonary acinar structure and function assesed by hyperpolaried 129Xe stimulated echo NMR" by Kern et al.

Three DZL lung cancer centers from Northern Germany, including Hannover Medical School, jointly implement the biggest German lung cancer screening study with more than 12,000 participants. After the successful kick-off meeting on May 26th, 2021, the study is now entering the phase of active participant enrollment.

We developed a novel method for ventilation imaging in a single breath-hold using proton-guided reconstruction of fluorinated gas MRI. The method is based on constraining the directional total variation between a functional 19F and an anatomic 1H image and enables imaging in patients with COPD in a single 6-second breath-hold.

At the annual meeting 2019, the ISMRM has awarded Dr. Andreas Voskrebenzev, physicist of Vogel-Claussen Imaging Lab, the Summa Cum Laude Merit Award for his research on quantification of regional lung ventilation using proton MRI.
Abstract title "FEV1/FVC Mapping with Dynamic MRI - A New Regional Lung Function Test"
Coauthors: Agilo Kern, Lea Behrendt, Filip Klimeš, Marcel Gutberlet, Gesa Pöhler, Frank Wacker, Jens Vogel-Claussen

We are part of a collaboration which could show the effect of Indacaterol/Glycopyrronium on pulmonary perfusion and ventilation in COPD patients. This in turn can be expected to also lead to an improvement of cardiac function.

We developed a novel method for regional mapping of microstructural and functional parameters of the human lung using inhaled hyperpolarized 129Xe. The method is based on the principles of chemical shift saturation recovery (CSSR) and incorporates several features in order to achieve major improvements in acquisition speed compared to CSSR spectroscopy.

We are part of a collaboration who did the first study to investigate the effects of a Indacaterol/Glycopyrronium combination therapy on cardiac function in patients with COPD and lung hyperinflation. Bronchodilation lead to an improvement in cardiac function, which is important because COPD patients frequently suffer from cardiovascular impairment.