Filip Klimeš, former PhD candidate of Vogel-Claussen Imaging Lab, has successfully defended his PhD thesis entitled "3D Dynamic functional lung ventilation magnetic resonance imaging". Focus of his work was on 3D Phase resolved functional lung (PREFUL) MRI to quantify ventilation during free breathing in healthy volunteers and patients with obstructive lung disease.

Two abstracts from members of Vogel-Claussen Imaging lab at this year's ISMRM annual meeting were among the highest rated 15% as judged by abstract reviewers.  The first Magna Cum Laude Merit Award is bestowed upon the abstract "Registration on different lung volumes and its influence on venlation and perfusion parameters derived by phase-resolved funconal lung MRI" by Klimes et al, the second award for "Pulmonary acinar structure and function assesed by hyperpolaried 129Xe stimulated echo NMR" by Kern et al.

Three DZL lung cancer centers from Northern Germany, including Hannover Medical School, jointly implement the biggest German lung cancer screening study with more than 12,000 participants. After the successful kick-off meeting on May 26th, 2021, the study is now entering the phase of active participant enrollment.

We have developed a novel 3D non-invasive technique for regional quantification of ventilation dynamics during free breathing. The method is based on our previously published 2D method called phase-resolved functional lung (PREFUL) MR imaging. In contrast to 2D techniques, 3D PREFUL offers higher spatial resolution, which might improve the sensitivity for early detection and monitoring of patients with lung disease.

We developed a novel method for ventilation imaging in a single breath-hold using proton-guided reconstruction of fluorinated gas MRI. The method is based on constraining the directional total variation between a functional 19F and an anatomic 1H image and enables imaging in patients with COPD in a single 6-second breath-hold.

The International Society for Magnetic Resonance in Medicine (ISMRM) has bestowed the Magna Cum Laude Merit Award upon Arnd Jonathan Obert, PhD student in Vogel-Claussen Imaging Lab, for his contribution at the ISMRM 2020 virtual conference.

Title of his work: "Volume-controlled 19F MR imaging of fluorinated gas wash-in"

Coauthors: Marcel Gutberlet, Agilo Luitger Kern, Frank K. Wacker, Jens Vogel-Claussen

Dr. Kaireit has been included in the Program of Hannover Medical School for clinician scientists (PRACTIS), a new clinician scienctist program funded by the German Research Foundation (DFG). PRACTIS provides 18 months scientific exemption and a grant with a volume of €27.000.

The Röntgen society of Lower Saxony, Bremen and Saxony-Anhalt has awarded Agilo Kern, physicist of Vogel-Claussen Imaging Lab, the Hans Meyer stipend for his work "Evaluation of ventilation, perfusion and structure of the lung in paediatric CF patients using 129Xe MRI". The award ceremony took place at this year's Radiology Congress North in Hamburg. Image: courtesy of Conventus Congressmanagement & Marketing GmbH.

Agilo Kern, physicist of Vogel-Claussen Imaging Lab, has successfully finished and defended his PhD thesis entitled "Functional lung magnetic resonance imaging using hyperpolarized 129Xe". Focus of his work was the advancement of imaging and spectroscopic methods to enable regional quantification of lung microstructural and functional parameters as well as their application in clinical studies.

At the annual meeting 2019, the ISMRM has awarded Dr. Andreas Voskrebenzev, physicist of Vogel-Claussen Imaging Lab, the Summa Cum Laude Merit Award for his research on quantification of regional lung ventilation using proton MRI.
Abstract title "FEV1/FVC Mapping with Dynamic MRI - A New Regional Lung Function Test"
Coauthors: Agilo Kern, Lea Behrendt, Filip Klimeš, Marcel Gutberlet, Gesa Pöhler, Frank Wacker, Jens Vogel-Claussen

We are part of a collaboration which could show the effect of Indacaterol/Glycopyrronium on pulmonary perfusion and ventilation in COPD patients. This in turn can be expected to also lead to an improvement of cardiac function.

We developed a novel method for regional mapping of microstructural and functional parameters of the human lung using inhaled hyperpolarized 129Xe. The method is based on the principles of chemical shift saturation recovery (CSSR) and incorporates several features in order to achieve major improvements in acquisition speed compared to CSSR spectroscopy.

We are part of a collaboration who did the first study to investigate the effects of a Indacaterol/Glycopyrronium combination therapy on cardiac function in patients with COPD and lung hyperinflation. Bronchodilation lead to an improvement in cardiac function, which is important because COPD patients frequently suffer from cardiovascular impairment.